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Sodium-glucose cotransporter 2 (SGLT2) inhibitors with proven benefits for HF should be used first in patients with HF regardless of HbA1c levels and should be maintained as long as there are no contraindications or side effects (RCT, General)

McGuire DK, Shih WJ, Cosentino F et al (2021) Association of SGLT2 inhibitors with cardiovascular and kidney outcomes in patients with type 2 diabetes: a meta-analysis

It raises crucial questions about the sustainability of treatment effects and the practical implications of potentially indefinite therapy

Polyphenols and certain spice compounds work through yet other pathways including inhibiting DPP-IV, the enzyme that breaks GLP-1 down within minutes of its release

"The part that concerns me the most is how insurance companies and employers are reacting to the inappropriate use," she said