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FIGURE 1 Drug abuse effects on metabolism and epigenetics The metabolic syndrome is a collection of metabolic abnormalities, including hyperinsulinemia, hypertension, dyslipidaemia, and abdominal obesity, and may be triggered by initial discrepancies at the cellular level in critical metabolic pathways

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The study was the first to report an association between semaglutide and a higher risk of NAION, although further studies (such as a larger, multicenter study or prospective clinical trials) are required to confirm findings and determine causality

Stable weight prior to surgery is necessary for optimal outcomes

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