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Arch Ophthalmol 108:689693

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Corticosteroids, some antidepressants, insulin-secreting medications, and others may alter the metabolic environment in ways that reduce retatrutide effectiveness

Administration of insulin subcutaneously, including insulin glargine products, has resulted in lipoatrophy (depression in the skin) or lipohypertrophy (enlargement or thickening of tissue) in some patients [see Dosage and Administration (2.2)]

Detoxification safely removes the drug from the system, while therapies like Cognitive Behavioral Therapy (CBT) address underlying behaviors and triggers

Broad model compatibility: Applicable to cell-based and non-clinical animal models examining remodeling, barrier function, and inflammatory signaling