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These effects contribute indirectly to better performance outcomes

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if stool is difficult to pass, try again later Consider a footstool to elevate feet during defecation, which may help optimize the anorectal angle Lifestyle measures: Engage in regular physical activity, which promotes healthy bowel motility Avoid prolonged sitting

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Similarly, SLC7A11 can be upregulated by LAPTM4B to inhibit ferroptosis or downregulated by circPOLA2 to promote it (35), yet the contextual switches governing its function are unknown