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S-Adenosyl-L-Methionine (SAMe) Plays a complex role in metabolism, functioning as a methyl group donor ( transmethylation reactions ), precursor of sulphur-containing compounds (transsulfuration pathway) , and in production of polyamines

doi: 10.1210/me.2003-0283 196 ZhangDLiuKHuWLuXLiLZhangQet al

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While genotype-specific responses remain incompletely understood, recent clinical trials have demonstrated that resveratrol exerts neuroprotective effects by mitigating neuroinflammation, enhancing mitochondrial function, and preserving blood-brain barrier integrity in patients with mild cognitive impairment (MCI) and early AD (Buglio et al., 2022)