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Rat hair metabolomics analysis reveals perturbations of unsaturated Fatty acid biosynthesis, phenylalanine, and arachidonic acid metabolism pathways are associated with Amyloid--Induced cognitive deficits

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10.1007/s11864-022-00986-w 72 PattouF.Kerr-ConteJ.WildD

By contrast, the effectiveness of some other oral antidiabetic drugs, such as glibenclamide, is dependent on adequate -cell function, and is therefore likely to decline as diabetes progresses, as shown in the UKPDS [35] and other studies [18, 36]

Adipose tissue is a physiologic reservoir of fatty acids, 311 when the storage capacity is exceeded, the accumulation of heterotopic lipids leads to lipotoxicity, thereby promoting low-grade inflammation and IR in the liver