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Cagrilintide is a synthetic amylin analogue investigated for its interactions with amylin receptor (AMY1-3) signaling pathways via a mechanistically distinct receptor pathway

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The analysis of the optimized structures of the MichaelisMenten complex indicate that the polar residues at position 13 (Cys or Ser) stabilize the deprotonated GS , which in turn acts as the catalytic Brnsted base and abstracts the proton at position C2 of substrate 7 (Extended Data Fig