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Treatment-specific hazard ratios were derived from the reduction in major cardiovascular adverse events with each treatment versus placebo, when added to standard of care [19, 48, 49]

Fitting these data to the Hill equation gave an apparent affinity for Na + in the low mM range (8.62 1.8 mM) (Supplementary Table 3), in line with previous studies 6,22,43,44 , with one report indicating a lower apparent K M of 0.3 mM 23 , which may reflect the choice of N -methyl-d-glucamine as a counter-ion versus Cs +

A clinical comparison of both medications mechanisms, average weight loss, side effects, and how our San Ramon providers choose between them for each patient

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