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For once-weekly preparations such as semaglutide (Ozempic, Wegovy) and dulaglutide (Trulicity), the time of day is generally less critical because these long-acting formulations maintain steady drug levels throughout the week

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Average weight loss was approximately 1419%

Another study found that GLP-1R activation in Brunners glands upregulated barrier defense genes, an effect entirely absent in GLP-1R knockout mice ( GLP-1 also modulates local inflammation through specialized cell populations

And I was like, 'Well, that's weird