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For moderate to severe cases the initial treatment will need to be broken up into 2 sessions, done one month apart

In an adjunctive epilepsy trial in pediatric patients (2 to 16 years), skin disorder (3%), alopecia (2%), dermatitis (2%), hypertrichosis (2%), erythematous rash (2%), eczema (1%), seborrhea (1%), and skin discoloration (1%) occurred more frequently in topiramate-treated patients compared to patients given placebo

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Brain is particularly vulnerable to oxidative damage due to higher oxygen consumption (about 20%) and lower antioxidant capacity than other organs (Xie et al., 2016