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10.1016/j.vph.2018.08.002 111 MaheshwariS

And an established system is often hard to overcome

Even though different RCDs are considered individual and independent cell death modes for classification purposes, interconnectivity and extensive crosstalk on the basis of the shared molecular signaling network, redundancy, feedback, and backup function are well documented [10]

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By contrast, while fibroblast growth factor (FGF) potential to induce skeletal muscle angiogenesis has been extensively investigated (for review see, i.e., [133]), the practical significance of such FGF, and even vascular endothelial growth factor (VEGF) [134], for muscle healing means an effect that is mostly limited to direct local administration combined with different modes of delivery [135]