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Tocris Bioscience

In the first study, postmenopausal women receiving Pt-141 experienced significant weight loss and an average decrease in daily caloric consumption (400 kcal/day) compared to the control group

(1) The researchers performed docking simulations and suggested that the tripeptide may form stable binding poses with VEGFR-2 through multiple hydrogen bonds, including interactions with residues such as LEU-37, LYS-117, CYS-116, and ASN-120

Petrelintide treatment was well-tolerated with no severe adverse events

Unlike other GLP-1 medications currently on the market, it is a small-molecule, nonpeptide compound a chemistry distinction with important practical consequences