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And so loosely speaking, this is an oversimplification, if you're a 3/4 or 4/4, in theory you should have a harder time clearing LDL particles from circulation

doi: 10.1016/j.clinthera.2017.05.354 79 LeonNLaCoursiereRYaroshDPatelRS

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Because prospective endpoint studies comprising large patient populations had just been published for saxagliptin (The Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus [SAVOR]Thrombolysis in Myocardial Infarction [TIMI] 53 trial [SAVOR-TIMI 53]

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Tirzepatide was also associated with greater decreases in systolic and diastolic blood pressure compared with placebo