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Over 48 weeks, retatrutide produced major body-weight reductions in humans

Although bariatric surgery can lead to weight loss of at least 25% and long-term weight maintenance, it is not scalable at the population level, and many people are still afraid to have surgery because of the possibility of complications, [135, 136]

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Nat Rev Drug Discov 8:500515 Kooij KL, Koster DIj, Eeltink E et al (2024) GLP-1 receptor agonist semaglutide reduces appetite while increasing dopamine reward signaling

& Goldman, J

The mechanism by which metformin causes GI side effects remains uncertain