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The gap between the 9 mg and 12 mg arms is narrow (about 2.3 percentage points) relative to the gap between either active arm and placebo, a pattern that has implications for dose selection in a real-world setting

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But we sometimes also add in things like creatine, amino acids, and other targeted supplements to help promote muscle health

In trials, retatrutide produced larger average weight loss (about 24.2% at 48 weeks versus roughly 20.9% for tirzepatide at 72 weeks)

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These cytokines play central roles in systemic inflammation and are elevated in conditions ranging from metabolic syndrome to cardiovascular disease