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In this context, postbiotics are more plausibly positioned not as primary weight-loss interventions, but as nutritional strategies that may be continued after GLP-1based pharmacotherapy to support metabolic stability, mitigate weight regain, and preserve lean mass during the post-treatment phase ( From a clinical nutrition perspective, postbiotics should not be positioned as weight-loss agents, nor as substitutes for pharmacological GLP-1 receptor agonists

Identification of predictive biomarkers, including GLP1R and FTO variants as noted above, could further guide personalized agent selection in this genetically heterogeneous population

The SELECT trial recruited 17,604 patients with pre-existing CVD and BMI 27 kg/m 2 , but without a history of diabetes

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