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Acknowledgement Thank you to Dr Rick Cutfield , Clinical Director of Endocrinology & Diabetes, Waitemat DHB for expert review of this article

The gut microbiome's role in GLP-1 regulation is an active area of research, with emerging evidence suggesting that microbial diversity and specific bacterial strains may influence incretin hormone secretion, but more human studies are needed to establish clinical significance

They may also worsen nausea or bloating for some patients

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Lilly similarly pointed to a "global pricing decline in the low- to mid- teens [percentages] this year." That comes after the landmark "most favored nation" deals both companies struck with President Donald Trump in November to slash obesity and diabetes drug costs, along with their recent efforts to further reduce direct-to-consumer prices for their treatments