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The mitochondrial release of apoptosis-inducing factor (AIF) and of endonuclease G (EndoG), which is extremely specific for myonuclei, occur, which are responsible for DNA fragmentation and chromatin condensation, as well as the collapse of the nuclear envelope ( Fig

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But here's the kicker: dehydrated cells slow down detoxification and diminish glutathiones efficacy

Portincasa P, Moschetta A, Di Ciaula A, Pontrelli D, Sasso RC, Wang HH, Wang DQH (2008) Pathophysiology of cholesterol gallstone disease