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this activates the tubulo-glomerular feedback responsible for afferent arteriole dilation and efferent arteriole constriction and, ultimately, leads to glomerular hyperfiltration and hypertension

117 Uncertainties regarding the optimal dose, treatment duration, and timing for neuroprotection relative to metabolic control also persist

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Furthermore, L-carnitine has been shown in some studies to act as a peripheral antagonist to thyroid hormone action