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MDPI PubMed Nature Claims of differential pro versus anti angiogenic activity derive primarily from animal corneal and tissue injury models and should not be extrapolated to tumor biology without human data

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Indications Symptomatic and short term treatment when the patient does not respond to the monotherapy of acute inflammatory processes with neurotic, musculoskeletal contractures-sciatica

Arthritis Res Ther (2006) 8(6):R172

Vegans, vegetarians, people over the age 50, anyone with stomach/bowel issues like chronic gastritis, leaky gut, IBS or celiac, and anyone who regularly takes medications such as Metformin, PPIs (used for GERD), H2 Receptor Antagonists (used for peptic ulcers), or anything that interferes with stomach acid production are actually at risk for vitamin B12 deficiency, and should supplement B12 regularly