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Sodium-glucose cotransporter inhibitors as antidiabetic drugs: current development and future perspectives

For example, in hereditary leiomyomatosis and renal cell cancer (HLRCC), a high level of fumarate caused by genetic mutation of fumarate hydratase induces the succination of Kelch-like ECH-associated protein 1 (KEAP1) accompanied by the consumption of a fumarate molecule 134,135

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10.1055/s-0036-1571297 129 SinghV.KeishamA.BhallaA.SharmaN.AgarwalR.SharmaR.et al (2018)