We then summarize a selection of biologically active nutrients that can be used as add-on or first-line therapy for intractable epilepsies, based on PubMed search criteria with combinations of keywords including nutrient, functional food, nutrition, nutritional, dietary supplement, supplementation, vitamin, mineral, fatty acids, epilepsy, epilepsy syndrome, refractory epilepsy, intractable epilepsy, drug-resistant epilepsy, temporal lobe epilepsy, genetic generalized epilepsy, and metabolic epilepsy, etc
Abbreviations GSH: Glutathione mGSH: Mitochondrial glutathione ML: Machine learning DL: Deep learning ROS: Reactive oxygen species OXPHOS: Oxidative phosphorylation KEGG: Kyoto encyclopedia of genes and genomes CCLE: Cancer cell line encyclopedia TCGA: The cancer genome atlas GO: Gene ontology TrSSP: The transporter substrate specificity prediction server GSSG: Glutathione disulfide PCA: Principal component analysis PC: Principal component RF: Random forest DT: Decision tree NB: Nave Bayes SVM: Support vector machine ROC: Receiver operating characteristic PRC: Precision-recall curve TP: True positive TN: True negative FP: False positive FN: False negative AUROC: Area under receiver operating characteristic curve AUPRC: Area under precision-recall curve MCC: Matthews correlation coefficient CNN: Convolutional neural network TPR: True positive rate References Pavlova NN, Zhu J, Thompson CB
Oocytes represent terminally differentiated, non-renewable germ cells that rely extensively on mitochondrial oxidative phosphorylation (OXPHOS) during maturation, fertilization, and early embryonic development [29, 30]
Research shows that glutathione deficiency can lead to increased susceptibility to diseases such as cancer, Parkinsons disease, and Alzheimers disease
Since your body uses glutathione constantly to process toxins and protect cells, a regular routine helps ensure your levels don't dip due to stress or environmental factors.
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