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Conventional drugs like metformin primarily exert their effects by improving IR, and studies have shown that they can modulate the gut microbiota, albeit with no significant impact on the levels of gut microbial metabolites (108)

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It appears to reset pathological gene expression, with observed effects on restoring function in dysfunctional systems

Dorsey, J

Older individuals who incorporated glycine and cysteine into their diets experienced increased glutathione levels, leading to improved fat burning and insulin resistance

Then hemochromatosis, you have high iron, and you can do things to mitigate these things and support them, but you're locked in, I like to look at genes that you're not locked in, but they increase susceptibility to a number of different things