When talking about glutathione in relation to the brain, it is important to address that the brain is especially sensitive to oxidative damage
Similarly, NEK7 is glutathionylated at Cys253 and requires GSTO1-dependent deSSG to interact efficiently with NLRP3 67
In short, glutathione has shown benefit among cystic fibrosis and AIDS patients who have decreased glutathione in the intestine, and it may show benefit in inflammatory conditions of the intestine, such as ulcerative colitis and Crohns disease, but this needs to be studied as well
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The report of Olesen et al
The diabetic patients were studied before and after 14 days of dietary supplementation with cysteine and glycine.