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For some patients, a GLP-1 or related medication may be appropriate
The STEP-9 trial showed patients with knee osteoarthritis taking semaglutide experienced marked improvements in pain scores along with significant weight reduction 39
With millions of Americans already taking GLP-1 medications and use continuing to grow, these effects on preventing and treating substance use disorders could have significant impact at the population level
Clinical studies have shown impressive results: Semaglutide Average weight loss: 1215% of body weight Tirzepatide Average weight loss: 1822% of body weight Many patients lose 1025 kg over 1218 months when combined with healthy eating and physical activity
Food noise : Many users report less obsessive thinking about food
Most RCTs failed to demonstrate a significant association between GLP-1 RAs and the occurrence of pancreatitis or pancreatic cancer, primarily because of their short duration and insufficient design for evaluating such risks
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