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If constipation persists beyond one week despite lifestyle modifications and over-the-counter laxatives, contact your healthcare provider for evaluation and alternative management strategies

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Each participant had one practice trial before the recorded official measurement

At 1.0 mg weekly, reductions reach 1.4 to 1.8 percentage points

11.8% weight loss achieved at 36 weeks in adults with obesity or overweight in VISTA Phase IIb trial HbA1c lowered by 1.9% at 26 weeks in adults with type 2 diabetes in SOLSTICE Phase IIb trial Extensive Phase III programme for elecoglipron planned including outcome trials 11.8% weight loss achieved at 36 weeks in adults with obesity or overweight in VISTA Phase IIb trial HbA1c lowered by 1.9% at 26 weeks in adults with type 2 diabetes in SOLSTICE Phase IIb trial Extensive Phase III programme for elecoglipron planned including outcome trials Positive results from the VISTA and SOLSTICE Phase IIb trials of elecoglipron, an oral small molecule GLP-1 receptor agonist (GLP-1 RA), unlock the next chapter in AstraZeneca's ambition to develop therapies that improve cardiometabolic and kidney health and reduce weight-related complications

doi: 10.3390/fishes9030099 74 DuncanS