In pivotal trials, weekly semaglutide produced roughly 1415% body-weight reduction at 68 weeks (STEP 1, NEJM 2021), and tirzepatide a dual GIP/GLP-1 co-agonist reached 1822% at one year (SURMOUNT-1, NEJM 2022)
Its a synthetic peptide, but it could boost the presence of the natural human growth hormone
Noya-Leal, F., van der Wielen, N., Behrens, M., Rouschop, S., van Arkel, J., Jongsma, M., Witkamp, R., Mes, J
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The safety of transdermal berberine and chromium during pregnancy and lactation has not been established
However, AMPs can have undesirable properties as drugs, including instability and toxicity