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The 1998 report found ipamorelin released GH without elevating ACTH or cortisol beyond what GHRH stimulation produced, and later work describes no significant elevation of prolactin, FSH, LH or TSH even at doses reported as more than 200-fold above the GH-releasing ED50

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Practitioner-reported injectable protocols commonly recommend subcutaneous doses of 250-500 mcg daily in a fasted state, whereas published human studies have evaluated oral doses between 1 and 5 mg daily

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