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A meta-analysis comparing the two compounds directly found retatrutide produced an average of 16.34 kg of weight loss compared to 11.82 kg for tirzepatide
The New England Journal of Medicine , 389(6), 514526
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Among these, CGRP causes prolonged vasodilation and is inhibited by 5-HT1B agonists in animal models, with 5-HT1D receptors serving a similar function in humans [48,63]
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