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The drivers of political action are complex and require the engagement of multiple actors that can muster public opinion and ultimately political will to enact change (528)

Three common reasons come up when I ask patients why they microdose weight-loss drugs

A medical review can help identify and manage these factors

When negative reactions arise, name them specifically: anger about a scar, disappointment in a contour, and approach each with a concrete step: medical review, scar therapy, or targeted strengthening exercises

In those on maximal dose of a GLP-1 RA (either subcutaneous or oral), I would initiate tirzepatide at the 5 mg weekly dose

So long as the brand-name options remain pricy, theres incentive for 503As to create these slightly changed versions