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10.1016/j.pharmthera.2020.107705 26 JiangL.TianW.WangY.RongJ.BaoC.LiuY.et al (2012)

128 This reduction is partially mediated through the upregulation of NLK and BCL2, which may contribute to the functional impairment observed in NK cells during aging

Curcumin inhibits NLRP3 inflammasome activation via P2X7R signaling, and apigenin reduces NLRP3 expression to improve cholesterol metabolism disorders

Rarely, metformin can cause lactic acidosis, a serious condition with symptoms like muscle pain, breathing difficulties, and severe fatigue

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