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This conservative start reveals any unexpected sensitivities

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4.4 Pharmacokinetics and bioavailability As described above, BBR has a low bioavailability and poor oral absorption, at less than 1% across various in vivo and in vitro studies [60]

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An oral on-demand option may reduce barriers to treat for patients, and potentially reduce the psychological burden associated with parenteral on-demand treatment use for not only patients living with HAE but also caregivers