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Switching from semaglutide to tirzepatide provides receptor novelty through GIP receptor activation while maintaining continuous appetite suppression

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GLP-1: Key to Blood Glucose Homeostasis GLP-1 is part of a group of metabolic hormones called incretin hormones that help decrease blood glucose levels

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These include leptin sensitizers, Y2R agonists (Eli Lilly, Novo Nordisk), amylin/calcitonin dual agonists (Nordic Biosciences, Amylin Pharmaceuticals), and ghrelin-targeting agents (Noxxon, Cytos) Novel mechanisms : There are several companies taking differentiated (non-incretin) approaches to obesity