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The immunomodulatory metabolite itaconate derived from the TCA cycle was significantly boosted as a result of decreased isocitrate dehydrogenase 2 and increased immune-responsive gene 1 and mitochondrial citrate carrier in dapagliflozin-treated mice, accounting for the inhibitory effect of dapagliflozin on NLRP3 inflammasome activation (155)

The way I understand it is, the five different hubs, different nutrients hit them

24 MhamdiA.HagerJ.ChaouchS.QuevalG.HanY.TaconnatL.et al

L-Carnitine helps your body use fat as fuel, so it can support fat burning when combined with exercise and a healthy diet

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On paper, that sounds like a dream for fat loss