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1.1 Brief history of GLP-1 discovery and development GLP-1 was discovered during research into the incretin effect, which occurs when oral glucose consumption leads to increased insulin production compared to intravenous glucose administration (Kreymann et al

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CYP2E1 is the principal CYP responsible for the metabolism of ethanol and is considered to be a major component of the microsomal ethanol-oxidizing system

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Oxidative stress-induced formation of methionine sulfoxide can spontaneously react with hydroxyl radical and generates methyl radical that non-specifically and non-enzymatically methylate DNA cytosine and may affect the epigenome 38

It also carries a critical surgical risk