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Evidence that hyperglycemia after recovery from hypoglycemia worsens endothelial function and increases oxidative stress and inflammation in healthy control subjects and subjects with type 1 diabetes

Opioid Use Disorder (OUD): Medications like buprenorphine and methadone are effective but have barriers to access and adherence

They create conditions under which proper nutrition and training produce exceptional results

It also reduces glucagon secretion to prevent excess glucose from entering your bloodstream

These dosing errors resulted from patients measuring and self-administering incorrect doses of the drug, and in some cases, health care professionals miscalculating doses of the drug

Candidates for supervised discontinuation: Maintained goal weight on a stable dose for 12 or more months Lost weight primarily through combined medication and lifestyle change (not medication alone) Consume 1.2 to 1.6 g protein per kg body weight daily Perform resistance training 3 or more times per week Sleep 7 or more hours nightly with good sleep architecture Have a BMI at goal of 25 or higher (patients who drop into the low-normal range have less metabolic buffer) No history of binge eating disorder or significant emotional eating patterns Even with this profile, the SURMOUNT-4 data suggests that roughly half of patients will regain meaningful weight within 12 months of stopping (Aronne et al., JAMA 2024)