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Retrieved from Giuntini, E

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Study participants were randomized to tirzepatide 15 mg (n = 398) or maximal tolerated dose plus metformin with intensified conventional care This could include a variety of approved medications for treating T2D along with metformin, including oral or injectable GLP-1 agonists or SGLT2 inhibitors, but not tirzepatide or insulin (n = 396)

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21 The anti-apoptotic effect of GLP-1 is mediated by increasing levels of the anti-apoptotic proteins Bcl-2 and Bcl-xL and activating cAMP and PI3K as well as PKB and EGFR-PI3K signaling pathways to reduce cysteine-3 activity