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This could complicate antibody-driven therapies
Discontinuance is also recommended if safety or tolerability issues arise
For example, the superoxide dismutase (SOD), catalase and Glutathione-S-transferase (GST), genetic polymorphisms may affect the cellular antioxidative ability
Compared to 4.1% in matched controls receiving weekly 250mg doses
That said, the Wegovy HD 7.2mg dose (approved March 2026) produced 20.7% in the STEP UP trial, which puts it very close to tirzepatide territory
Abbreviations AD: Alzheimers disease CCK: Cholecystokinin CNS: Central nervous system CRF: Corticotropin-releasing factor DPP4i: Dipeptidyl peptidase-4 inhibitor FDA: Food and Drug Administration FOS: Fructooligosaccharides GERD: Gastroesophageal reflux disease GI: Gastrointestinal GIP: Glucose-dependent insulinotropic polypeptide GLP-1: Glucagon-like peptide-1 GLP-1 RA: Glucagon-like peptide-1 receptor agonist IPPW: Isolated pyloric pressure wave MMC: Migrating motor complex PYY: Peptide YY RCT: Randomized controlled trial SCFA: Short chain fatty acid T2DM: Type two diabetes mellitus References Yao H, et al
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