POI: premature ovarian insufficiency
Sun Y, Zuo X, Zheng X, Zhou F, Liang B, Liu H, Chang R, Gao J, Sheng Y, Cui H, Wang W
Challenges: Regulatory complexities across regions, peptide stability and bioavailability, and the need for rigorous quality control
Of the 50 children with T1D, 25 had both detectable I-r-Abs and HLA genetic susceptibility to T1D, 17 had detectable I-r-Abs, but were not typed for HLA, 2 had HLA genetic susceptibility to T1D, but did not have detectable I-r-Abs, 2 had detectable I-r-Abs, but did not have HLA genetic susceptibility to T1D and 4 were neither tested for I-r-Abs nor HLA typed (Table 1)
The rise in plasma GLP-1 is clearly meal related with fasting levels of about 5-15 pM and stimulated levels of 40-80 pM in normal men (59, 90)
The Cosmetic Ingredient Review's own literature search found no useful efficacy studies on this ingredient