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Some studies have indicated a neutral, or even an increased, response

Glp1r expression was higher in afferent arterioles than in the renal artery (Supplemental Figure 4C)

For instance, IGF-I, IGFBP-2 and IGFBP-5 levels rise, while IGF-IR and IGFBP-3 levels lessen (82, 102104)

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Similarly, ICV injection of Ex-4 increased c-fos expression in alpha-melanocyte stimulating hormone (alpha-MSH)-immunoreactive neurons in the ARC of mice (Dalvi et al., 2012)