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By diminishing the DNA binding capacity of hypoxia response elements in Caco-2 and IEC-6 cells, contradictory findings suggest that butyrate suppresses the transcriptional activity of HIF-dependent hypoxia-sensitive genes 79

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at least twice yearly if stable and meeting targets (per ADA guidelines) Fasting blood glucose and self-monitoring blood glucose logs Body weight at each visit to track response and adjust medications Blood pressure monitoring, as weight loss may affect cardiovascular parameters Symptom Monitoring is equally important

References 1 MukherjeeMStoddartAGuptaRPNwaruBIFarrAHeavenMet al

Oncol Rep 25:16991703

This care helps lower the risk of harmful side effects