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Currently, 264 ferroptosis-driving targets and 238 ferroptosis-inhibition targets have been identified

It also suppressed NF-B p65 and p38 MAPK signaling pathways and protected the lungs by reducing reactive oxygen species (ROS) production, stimulating superoxide dismutase (SOD), while decreasing TNF- and IL-6 production [ 46 ]

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To more precisely examine the extent to which mitochondrial GSH depletion impacts erythropoiesis, we additionally generated a mouse model in which mitochondrial GSH import is disrupted specifically in the erythroid lineage (conditional SLC25a39-KO mice, ErGFP-cre

10.1016/j.bbmt.2013.02.010 19 DavilaJ.StanekJ.O'BrienS