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The Phase 3 trial program tested 4 mg, 9 mg, and 12 mg subcutaneous once-weekly doses in human participants [1][2]

The bridge from genes changed to cell function changed is still half-built, and most of the published work leans on dermal fibroblasts, with far less on the cardiac, lung, or joint varieties, which makes generalizing across tissue types shakier than it sounds

This is the form that can directly neutralize free radicals and exert its detoxifying and skin-brightening effects

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I suspect the absolute risk is low for short-term use, but we do not actually know, and that uncertainty alone is a strong argument against chronic use

| DOI: 10.1519/JSC.0b013e3181c63bd5 Wax B, Kerksick CM, Jagim AR, Mayo JJ, Lyons BC, Kreider RB