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Several practical factors may explain fatigue during GLP-1 therapy: Reduced food intake due to appetite suppression can lead to lower energy consumption Gastrointestinal side effects like nausea can be physically draining Adaptation to metabolic changes as your body adjusts to the medication For people with diabetes who take insulin or sulfonylureas (like gliclazide) alongside GLP-1 medications, low blood glucose (hypoglycaemia) may cause fatigue

It also decreases hunger and creates a feeling of fullness

People with type 2 diabetes, heart disease, sleep apnea, or other obesity-related conditions are also strong candidates for this treatment

This means you inject the same day each weekMonday morning, for exampleto maintain stable blood levels of the active compound

But not always the safest. People who put in average weights on the online intake forms were still offered the antidiabetic drug, Narang told CNN

Tirzepatide vs Semaglutide Dosing Schedules Both medications use weekly subcutaneous injections with gradual dose titration