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To achieve the enrollment target for the substudy (approximately 100 participants), the main study was overenrolled ( n = 338 versus planned n = 300)

This shift toward more comprehensive hormonal modulation could signal the end of one-dimensional weight loss drugs and usher in an era of personalized peptide-based medicine

This difference compounds over time

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Tirzepatide works by targeting both GLP-1 and GIP receptors, resulting in greater weight loss and better glucose lowering than medications that target GLP-1 alone, said Isaacs

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