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Its a question many people are asking, given the fact that B12 is so dramatically effective in individuals who are truly B12 deficient, says Ralph Green, M.D., Ph.D., FRC Path, a distinguished professor and emeritus chair in the department of pathology and laboratory medicine at U.C

176,177 It will further fail when attempting to describe how allosteric rescue mutations 178,179 work (albeit not other rescue mutations, e.g., refs (180183)), how allosteric drugs are able to block the active site, and how mutations countering them can be overcome

The aim is to reduce progression and to reduce the need for future knee replacement or other knee surgeries

Goldstein's group at George Washington University in the 1960s-70s

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