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Check your needle gauge

The medication also reduces cravings for high-calorie foods and increases the brain's recognition of satisfaction at smaller portion sizes, making it easier to maintain a calorie deficit without constant hunger

What dietary changes should I make while taking the medicine

Practical approaches: Start retatrutide at the lowest dose and titrate slowly Follow the recommended retatrutide titration schedule rather than jumping to high doses If weight loss exceeds 3 pounds per week consistently, consider slightly increasing caloric intake Ensure you are eating at least 1,200 calories daily, preferably 1,400-1,600 Do not skip meals even when appetite is suppressed The phase 2 trial data showed that starting at 2mg (rather than 4mg) significantly reduced GI side effects

3.3 Long-acting GLP1 receptor agonists: Once-weekly 3.3.1 Semaglutide SMG is an analog of long-acting GLP-1, mainly used to control T2DM, and is also suitable for promoting weight loss in people with mild obesity (95, 96)

They followed 173 RA patients with overweight or obesity who were prescribed and actually took a GLP-1 medication (semaglutide or tirzepatide) between 2018 and 2024, and compared them to 42 patients who were prescribed one but never took it