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For example, certain FTO variants associate with greater baseline appetite dysregulation, potentially contextualizing why some individuals benefit from GLP-1 earlier in their metabolic journey

They identified exendin-4, a molecule strikingly similar to the human GLP-1 hormone, which stimulates insulin production, according to the Journal of Biological Chemistry

Limitations Oral bioavailability is generally lower than injectable forms

Diabetologia 60, 15661576

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doi: 10.1001/jama.2025.14392 45 GuedesTPMartinsSCostaMPereiraSSMoraisTSantosAet al