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High sugar consumption can lead to insulin resistance, impairing this conversion and potentially triggering hypothyroid symptoms despite treatment [16]

Exp Gerontol 38(5):491498 Uthus EO, Brown-Borg HM (2006) Methionine flux to transsulfuration is enhanced in the long living Ames dwarf mouse

J Appl Physiol 128:14971505

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doi: 10.1161/01.atv.0000183883.72263.13

The therapeutic outcome is determined by what happens during the activation window, not how long the peptide remains detectable