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Dattilo et al., 2023

In multiple instances, tested samples contained zero active medication despite marketing claims

Regular use of a stool softener or fiber can help with this

Dihexa's plasma half-life is estimated at 24 hours in rodent models, though CNS half-life may differ due to blood-brain barrier kinetics and receptor internalization dynamics

More rounded fragments arise in significant dyserythropoiesis (such as severe myelodysplasia, membrane disorder or megaloblastic states), these are also important to diagnosis, but have a different origin

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